Journal information

‘CURRENT TRENDS IN GENOMIC MEDICINE’ 

Editor in Chief:

Professor Dhavendra Kumar, MD FRCP FRCPCH FACMG
Institute of Cancer & Genetics/ Institute of Molecular & Experimental Medicine, Cardiff University School of Medicine,
University Hospital of Wales, Cardiff, UK

Introduction
The new millennium is the ‘Genomics Millennium’. Rapid advances and the wealth of information related to the science of genetics and genomics have wide-ranging applications in all aspects of human health. The philosophy of the practice of medicine is changing as society is acknowledging the impact of the completion of the Human Genome Project. Expectations of the public, media and politicians are exceeding all limits. Human health is now intricately linked to genes, genetics and genomics.

In recent years, a new aspect of clinical medicine has emerged with emphasis on the medical and health implications of genomics. This is appropriately named ‘genomic medicine’ and holds great promise for human health. This new approach to health care uses the knowledge of an individual’s genomic make-up to identify those that are at a higher risk of developing certain diseases, and to intervene at an earlier stage to prevent these diseases. In addition, the genomic variation and specific genomic characteristics will enable researchers to develop tools to detect toxins, nutrients, microbes and other environmental agents that could have negative or positive implications for individual or community health. This would enable developments of better treatments and cures. The major role of genomic medicine lies in ‘prediction, prevention and promotion’ and developing strategies for holistic health care of an individual, commonly referred to as ‘personalized medicine’. The whole field is exciting and has attracted the interest of several institutions, pharmaceutical organizations, and researchers. The output from this tremendous research effort is currently channeled through existing genetics journals with only peripheral coverage of genomic medicine. There is a clear need and scope for a new journal to fill this gap. The Genomic Medicine Foundation plans to launch a new flagship journal to focus on genetic and genomic aspects of modern and future clinical medicine and health. This is appropriately named ‘Current Trends in Genomic Medicine’.

The ‘Current Trends in Genomic Medicine’ is a new international journal aimed at providing and communicating knowledge and developments in the field of the science of genetics and genomics as applied to human health. It will include major issues in the fast developing practice of medical and clinical genomics, drug discovery and development, and other related developments relevant to promoting human health and prevention of disease. Emphasis will also be on ethical, moral and legal matters as applied to genomics and human health. A separate section will cover public interests, including media coverage of key and controversial topics related to public health and government policies on genomics based health service.

Aims/Objectives
The ‘Current Trends in Genomic Medicine’ is the new international biomedical journal. The main aim of the journal is to provide an excellent resource for the publication of peer-reviewed original research papers, review articles and commentaries on a wide range of genomics-related fields in medicine with proven and/or likely implications for the current and future practice of clinical medicine and preventive medicine.

Objectives of the journal are very broad because the whole field of genomics is wide and rapidly expanding. In general, the journal would focus on the following key areas:

  • Advances in knowledge and developments in a number of genomic-related specialist fields that are shown to/likely to have implications for clinical and preventive medicine. Examples of these fields include developmental biology, molecular biology, metabolomics, epigenomics, clinical proteomics, microbial genomics, high-throughput genomic technologies (microarrays and next generation sequencing), bioinformatics, pharmacogenomics, nutrigenomics, toxicogenomics, personalized & stratified medicine, cancer genomics, population genomics, and stem cell genomics.
  • Applications of genomics in understanding the complex medicaldiseases (coronary artery disease, diabetes mellitus, bronchial asthma etc.), common cancers, skin diseases, and psychiatric diseases. For example, genome wide studies using single nucleotide polymorphisms (SNPs) and genome sequence variations.
  • Applications of genomics in infectious diseases, for example susceptibility, protection, antimicrobial therapy and development of vaccines.
  • Genomics-based development and evaluation of new drugs including adverse or favourable response to pharmacological and toxic substances.
  • Impact of medical genomics on public and population health.
  • Integration of genomics in medical and health education.
  • Debate and discussion on social, legal, moral and ethical issues related to medical genomics.
  • Grand round discussions of clinical cases supported by genomics-related diagnostic and therapeutic applications.
  • Reporting and discussion of books, conferences and reports on contentious issues in human and medical genomics.

Target readership and audience
The journal is aimed at practicing physicians and clinical scientists from a broad range of medical and surgical specialties, including community and public health. This would provide an excellent resource for publication and discussion from a wide range of physicians, clinical scientists, research and academic professionals, and genetic professionals engaged in original and applied research in human or medical genomics. Other possible readers and subscribers could include scientists and academic professionals working in related areas such as developmental biology, molecular biology, pharmacogenomics, microbial genomics and clinical teratology/ toxicogenomics.

Format of the Journal
The ‘Current Trends in Genomic Medicine’  is an on-line open access journal. All accepted articles and submitted manuscripts shall be published soon after acceptance. All material will be put together in quarterly issues.

The Journal format shall include the following major sections:

  1. Editorial – from the editorial team or an invited leading article on a subject of major or topical interest
  2. Review article on a selected topic of wide interest, this will be invited or commissioned to a voluntary author or an institution.
  3. Original papers based on ethically approved and peer-reviewed research work supported by relevant experimental work and statistical data.
  4. Short reports on clinically relevant research in any of the genomics-related fields.
  5. Grand round proceedings of clinical or clinico-pathological meetings in any major hospital or medical institution highlighting the use of genomics- based diagnostic and/or therapeutic techniques.
  6. Media (Genome) mirror to provide unbiased coverage on developments in genetics or genomics including news items appearing in the press, Internet, radio and television.
  7. Medico-legal Insurance matters including commentary on government policies/ legislature
  8. Genomics News Editorial comments on recent publications in other related journals.
  9. Letters to Editor usually comments and views on papers and articles published in Genomic Medicine
  10. Books received and Reviewscommissioned by one of the editors on books sent by publishers.
  11. Conferences/ Calendar
  12. General information about editorial matters, subscriptions and instructions to authors.

Authors’ instructions/ Manuscript submission
Submission of a manuscript to ‘Current Trends in Genomic Medicine’  implies that the work has not been previously published, except in part in the form of an abstract, proceeding of a conference or professional meeting, or as part of a published lecture, review or thesis. All manuscripts should accompany the following information-

  • Name of any other journal(s) where the paper is under consideration for publication.
  • Evidence that the manuscript is approved for publication by all co-authors.
  • Validation and permission from the responsible authorities at the Institution where the work was carried out.
  • Evidence for any locally, nationally or any other form of ethical approval supporting the work submitted for publication
  • Statement on ‘conflict of interest’ by all co-authors or the Institution.
  • Copyright transfer statement duly signed by all authors or contributors.                   

Manuscripts should be submitted in the electronic version in one of the commonly used programs including Microsoft Word, RTF, PDF etc. Send two hard copies of the manuscript along with figures/tables and an IBM-compatible floppy disk by regular post. Return e-mail address and full postal address, a telephone number and fax number should be provided with all e-mail submissions.

The submission requirements of “Current Trends in Genomic Medicine” conform to those presented by the International Committee of Medical Journal Editors in “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” and the “Declaration of Helsinki: Recommendations Guiding Physicians in Biomedical Research Involving Human Subjects” (JAMA 1997; 277:927-934). The complete text of these guidelines appears in Annals of Internal Medicine 1997; 126:36-47, or New England Journal of Medicine 1997; 336:309-315.

Covering letter
Each manuscript should have a covering letter from the corresponding author. The letter should include:

  • Full title of the paper/article.
  • Category of manuscript being submitted, for example original article, letter to the editor etc.
  • Mailing address, a telephone number and fax numbers, and e-mail address of the corresponding author.
  • Brief statement about all authors’ agreement for submission
  • Confirmation of ethical approval, if appropriate, from a relevant regulating body or an official ethical committee.

The covering letter should also include author(s)’ justification as to why the paper is particularly suited for publication in Genomic Medicine.

Title page
The first page of the manuscript should contain on separate lines, the full title of the article, authors’ names and institutions. If the title exceeds 40 letters and spaces, a short title, not exceeding that limit, will be required to be used as a running head. The first page should also include the full mailing address, e-mail address (if available), and telephone and fax numbers of the author to whom all communications and proofs should be sent.

Sections
Papers and articles must be clearly divided into the following sections: Abstract (not exceeding 200 words); Key words; Introduction; Materials and Methods; Results; Discussion; Acknowledgements; References; Legends; and Figures/Tables. Editors are aware that this format may not be applicable for review articles, news/commentaries, and letters to editor and brief communications.

Key words
Four to nine key words for indexing purpose should be given. These should be arranged in alphabetical order and, when possible, adjusted to the Medical Subject Headings of Index Medicus.

References
References should be numbered consecutively in the order in which they appear in the text. References should be identified in the text, tables and figures by Arabic numerals and appearing in square brackets. In case of consecutive references, numbers can be used with a hyphen, for example [1-5]. Papers or articles accepted for publication may be included with abbreviated title of the article, name of journal followed by (in press).

All papers and articles not yet accepted can be included as (submitted). The references must be verified by the author(s) against the original documents. Title of journal articles should be abbreviated in accordance with the style used in PubMed, PubMed central, and Current contents.

Examples:

  1. Stoll C. Problems in the diagnosis of Fragile X Syndrome in young children are still present. Am J Med Genet 2001;100:110-115
  2. Seyda A, Newbold RF, Hudson TJ, Verner A et al. A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13. Am J Hum Genet 2001; 68:386-396.
  3. Hayden MR. Huntington’s disease. In: Pulst S-M eds. Neurogenetics. Oxford University Press, 2000.

Acknowledgements
The journal will include acknowledgements on those directly involved in the study but not included as co-authors. Sources of financial support and industrial affiliations of those involved should also be included.

Legends
Legends should be typed on a separate page and attached at the end of the paper.

Figures
All illustrations, graphs, drawings, or photographs are referred to as figures (abbreviate as Fig./Figs.). These should be numbered in sequence with Arabic numerals. Each figure should be identified with a figure number on the back. Any line drawings that are to appear in the illustrations should be large enough for the necessary reduction. In general, photographs should be one and a half times larger than the block and must be submitted as mounted glossy enlargements showing good detail with adequate contrast. Colour illustrations may be published at the editor’s discretion. There may be an additional charge for colour illustrations, which will be quoted by the publisher. Submit original colour prints.

Tables
The tables should be typed on separate pages. These should be numbered consecutively with Arabic numerals. The approximate location of the table should be indicated by a circled marginal note.

Abbreviations and symbols
All abbreviations and symbols should follow generally accepted standardised terms. Unfamiliar abbreviations should be defined when first used in the text. For further details, see Units, Symbols, and Abbreviations: A Guide for Medical and Scientific Editors and Authors. (available from The Royal Society of Medicine Press, 1 Wimpole Street, London, W1M 8AE, England).

Proofs
Page proofs only will be sent. Only minor revisions will be allowed without extra cost.

Publishing
The final version of the accepted article/paper should not normally exceed twenty thousand words. However, longer manuscripts would be published subject to additional page charge (see Tariff for Publishing charges). Each manuscript will have logged information for example ‘date received’, ‘date revised’ and ‘date accepted’.

Tariff
Current Trends in Genomic Medicine is the official journal of the Genomic Medicine Foundation (UK) Ltd., a ‘not for profit’ organization established for the sole purpose of promoting and contributing to medical and health applications of genome sciences and technologies. Each paper or article published in the journal would be published subject to the following charges. However, these charges could be waived by the Editor in Chief on recommendations from the Editorial Board. Examples of circumstances for the waiver of publishing charge might include an editorial, an invited article, a commissioned article leading a set of specialist manuscripts or a paper or article received/ accepted from an under-resourced organization in a developing or underdeveloped country.

List of Charges

£350 Any paper/ article up to 5,000 words (inclusive of title/ references) along with 2 illustrations (graph , clinical photo, copy of the laboratory report etc. ) and 2 tables

£500 Manuscript length up to 10,000 words (inclusive title/ references) along with maximum 4 illustrations (graph , clinical photo, copy of the laboratory report etc.) and 3 tables

£750 Manuscript length up to 15,000 words (inclusive title/ references) along with maximum 5 illustrations (graph , clinical photo, copy of the laboratory report etc.) and 4 tables.

£1000 Manuscript length up to 20,000 words (inclusive title/ references) along with maximum 6 illustrations (graph, clinical photo, copy of the laboratory report etc.) and 5 tables.

£1500 Manuscripts over 20,000 words (Maximum 40,000) and more than 6 illustrations and/or 6 tables (subject to final size of the manuscript and individual agreement)

Copyright Information
Authors and contributors submit their paper on the clear understanding that the work has not been previously published, or submitted elsewhere for publication. All authors and contributors are expected to have read and approved the final version before its submission to the ‘Current Trends in Genomic Medicine’. The submission of the manuscript by the authors means that the authors agree to assign exclusive copyright to the publisher (The Genomic Medicine Foundation, UK Ltd.) if and when the manuscript is accepted for publication. On acceptance, the corresponding author will be sent a Copyright Assignment form returned duly signed by all the co-authors. The work shall not be published elsewhere in any language or in any format without the written permission of the publishers. No material published in the journal can be reproduced in any form or stored on microfilm or videocassette or in any other electronic/ digital manner including databases, Face book , Twitter and Open tube.

Peer review
The journal has adopted a stringent peer-review process allowing only high quality and properly validated original research papers and articles.  The peer-review would not be necessary for editorial, invited review or invited commentary. Exceptionally, however, this might be waived for other manuscripts at the discretion of the leading editor. In most cases two reviewers would be assigned to one manuscript, except when the leading editor would have carried out an independent review. In an exceptional case, any outstanding manuscript could be recommended without peer-review for publication by the lead editor or editor in chief. Reviewers would be selected from the journal’s database of potential reviewers or identified from on-line searches matching close to the subject of the manuscript. Each reviewer would normally be allowed to take 2 weeks from the time of receiving the manuscript. A recommendation for publication might include one of the following-

  • Accept- without peer review/ editor in chief’s discretion
  • Accept- after lead editor’s review with agreement from editor in chief
  • Accept- after full peer- review
  • Accept- subject to satisfactory minor revision
  • Accept- subject to major revision approved by the lead editor
  • Reject- not appropriate for the journal
  • Reject-incompletely written or technical errors
  • Reject-by editor in chief without assigning lead editor
  • Reject- following lead editor’s review
  • Reject- after full peer review
  • Resubmit as per lead editor’s instructions